6CEB

Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Insulin receptor	polymer	917	104736.8	2	UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) Pfam (PF17870)	Homo sapiens (Human)	IR
2	C, H (M, P)	Insulin receptor	polymer	30	3671.2	2	UniProt (P06213)	Homo sapiens (Human)	IR
3	D, F (K, N)	Insulin A chain	polymer	21	2383.7	2	UniProt (P01308)	Homo sapiens
4	E, G (L, O)	Insulin B chain	polymer	30	3403.9	2	UniProt (P01318) Pfam (PF00049)	Ovis aries
5	I, K, N, P (C, E, H, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	4	In PDB GlyTouCan (G21290RB)
6	J, O (D, I)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
7	L, Q (F, Q)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
8	M, R (G, R)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	2	In PDB GlyTouCan (G86851RC)
9	S, T, U, V (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, B: 1 - 917 (UniProt: P06213)

PDB	External Database	Details
His 144	Tyr 171	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	228391.3
Branched	Number of molecules	10
	Total formula weight	5038.8
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	234314.8

*Water molecules are not included.