6CEB

Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry

Functional Information from GO Data

Chain	GOid	namespace	contents
K	0005179	molecular_function	hormone activity
K	0005576	cellular_component	extracellular region
L	0005179	molecular_function	hormone activity
L	0005576	cellular_component	extracellular region
N	0005179	molecular_function	hormone activity
N	0005576	cellular_component	extracellular region
O	0005179	molecular_function	hormone activity
O	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCTSiCSlyqLenyC

Chain	Residue	Details
K	CYS6-CYS20

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1460
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	HIS1-VAL731
B	HIS1-VAL731

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Insulin-binding => ECO:0000305

Chain	Residue	Details
A	PHE39
B	PHE39

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER373
A	SER380
B	SER373
B	SER380

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	TYR374
B	TYR374

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862, ECO:0000269|PubMed:2983222

Chain	Residue	Details
A	ASN16
B	ASN16

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site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:23302862

Chain	Residue	Details
A	ASN25
A	ASN111
A	ASN255
B	ASN25
B	ASN111
B	ASN255

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site_id	SWS_FT_FI7
Number of Residues	14
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN78
B	ASN606
B	ASN624
B	ASN671
B	GLU755
B	THR906
A	ASN295
A	ASN606
A	ASN624
A	ASN671
A	GLU755
A	THR906
B	ASN78
B	ASN295

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:23302862

Chain	Residue	Details
A	ASN215
B	ASN215

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site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147

Chain	Residue	Details
A	ASN337
A	ASN397
B	ASN337
B	ASN397

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16894147, ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	ASN418
B	ASN418

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site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1472036, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN514
B	ASN514

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site_id	SWS_FT_FI12
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2983222

Chain	Residue	Details
A	PRO742
B	PRO742

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site_id	SWS_FT_FI13
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973

Chain	Residue	Details
A	GLY893
B	GLY893

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 246

Chain

Residue

Details

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