6CD6
Crystal Structure of the Human CAMKK1A in complex with GSK650394
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Calcium/calmodulin-dependent protein kinase kinase 1 | polymer | 290 | 32702.7 | 4 | UniProt (Q8N5S9) Pfam (PF00069) | Homo sapiens (Human) | CaMKK 1, CaM-kinase IV kinase, Calcium/calmodulin-dependent protein kinase kinase alpha, CaMKK alpha |
| 2 | E, G, I, K (A, B, C, D) | 2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid | non-polymer | 382.5 | 4 | Chemie (DXV) | |||
| 3 | F, H, J, L (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 110 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 124 - 411 (UniProt: Q8N5S9)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | - | expression tag |
| Met 123 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130810.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1671.6 | |
| All* | Total formula weight | 132482.4 |
