6CCB
Crystal structure of 253-11 SOSIP trimer in complex with 10-1074 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glycoprotein 41 | polymer | 162 | 18312.9 | 2 | UniProt (B2YFS0) Pfam (PF00517) | Human immunodeficiency virus 1 | |
| 2 | C, F (C, G) | Glycoprotein 120 | polymer | 486 | 54179.0 | 2 | UniProt (B2YFS0) Pfam (PF00516) | Human immunodeficiency virus 1 | |
| 3 | D, G (D, H) | 10-1074 FAB heavy chain | polymer | 237 | 25488.5 | 2 | Homo sapiens (human) | ||
| 4 | E, H (E, L) | 10-1074 Fab light chain | polymer | 215 | 23237.8 | 2 | Homo sapiens (human) | ||
| 5 | I (F) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
| 6 | J (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 7 | K (J) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 8 | L (K) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 9 | AA, BA, CA, DA, EA... (C, G, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 32 | Chemie (NAG) |
Sequence modifications
A, B: 512 - 664 (UniProt: B2YFS0)
C, G: 31 - 506 (UniProt: B2YFS0)
| PDB | External Database | Details |
|---|---|---|
| Cys 605 | Thr 603 | engineered mutation |
| Gly 665 | - | expression tag |
| Thr 666 | - | expression tag |
| Lys 667 | - | expression tag |
| His 668 | - | expression tag |
| His 669 | - | expression tag |
| His 670 | - | expression tag |
| His 671 | - | expression tag |
| His 672 | - | expression tag |
| His 673 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 28 | - | expression tag |
| Thr 29 | - | expression tag |
| Gly 30 | - | expression tag |
| Asn 295 | Thr 292 | engineered mutation |
| Thr 297 | Ile 294 | engineered mutation |
| Cys 501 | Ala 499 | engineered mutation |
| Gly 507 | - | expression tag |
| Arg 508 | - | expression tag |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Arg 511 | - | expression tag |
| Arg 512 | - | expression tag |
| Arg 513 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 242436.2 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4940.4 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 7078.7 | |
| All* | Total formula weight | 254455.2 |
