6CBD
Crystal Structure of Human Argonaute2 Bound to Three Tryptophans
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein argonaute-2 | polymer | 859 | 97378.2 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) In PDB | Homo sapiens (Human) | hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
2 | B | Guide RNA | polymer | 21 | 6547.9 | 1 | synthetic construct | ||
3 | C | Target RNA | polymer | 11 | 3538.2 | 1 | synthetic construct | ||
4 | A | TRYPTOPHAN | non-polymer | 204.2 | 3 | Chemie (TRP) | |||
5 | A, B | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 3 | Chemie (IPA) | |||
6 | A, B, C | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
7 | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
PDB | External Database | Details |
---|---|---|
Asp 387 | Ser 387 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 107464.3 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 865.9 | |
All* | Total formula weight | 108330.1 |