6C5V

An anti-gH/gL antibody that neutralizes dual-tropic infection defines a site of vulnerability on Epstein-Barr virus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Envelope glycoprotein H	polymer	697	77091.5	1	UniProt (K9US75)	Human herpesvirus 4 (HHV-4)	gH
2	B (B)	Envelope glycoprotein L	polymer	139	15145.4	1	UniProt (Q1HVF6) Pfam (PF11108)	Human herpesvirus 4 (HHV-4)	gL
3	C (C)	Glycoprotein 42	polymer	227	25356.9	1	UniProt (P0C6Z5)	Human herpesvirus 4 (HHV-4)	gp42
4	D (H)	Antibody Fab AMMO1 heavy chain	polymer	226	23982.9	1		Homo sapiens
5	E (L)	Antibody Fab AMMO1 light chain	polymer	216	23095.5	1		Homo sapiens
6	F (D)	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G56014GC)
7	G, H, I, J, K... (A, B, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)

Sequence modifications

A: 19 - 679 (UniProt: K9US75)

PDB	External Database	Details
Met -6	-	expression tag
Asp -5	-	expression tag
Ala -4	-	expression tag
Met -3	-	expression tag
Lys -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Leu 1	-	expression tag
Cys 2	-	expression tag
Cys 3	-	expression tag
Val 4	-	expression tag
Leu 5	-	expression tag
Leu 6	-	expression tag
Leu 7	-	expression tag
Cys 8	-	expression tag
Gly 9	-	expression tag
Ala 10	-	expression tag
Val 11	-	expression tag
Phe 12	-	expression tag
Val 13	-	expression tag
Ser 14	-	expression tag
Pro 15	-	expression tag
Ser 16	-	expression tag
Ala 17	-	expression tag
Ser 18	-	expression tag
Gly 680	-	expression tag
Ser 681	-	expression tag
Gly 682	-	expression tag
Ser 683	-	expression tag
Gly 684	-	expression tag
His 685	-	expression tag
His 686	-	expression tag
His 687	-	expression tag
His 688	-	expression tag
His 689	-	expression tag
His 690	-	expression tag

B: 24 - 137 (UniProt: Q1HVF6)

PDB	External Database	Details
Met -1	-	expression tag
Asp 0	-	expression tag
Ala 1	-	expression tag
Met 2	-	expression tag
Lys 3	-	expression tag
Arg 4	-	expression tag
Gly 5	-	expression tag
Leu 6	-	expression tag
Cys 7	-	expression tag
Cys 8	-	expression tag
Val 9	-	expression tag
Leu 10	-	expression tag
Leu 11	-	expression tag
Leu 12	-	expression tag
Cys 13	-	expression tag
Gly 14	-	expression tag
Ala 15	-	expression tag
Val 16	-	expression tag
Phe 17	-	expression tag
Val 18	-	expression tag
Ser 19	-	expression tag
Pro 20	-	expression tag
Ser 21	-	expression tag
Ala 22	-	expression tag
Ser 23	-	expression tag

C: 33 - 223 (UniProt: P0C6Z5)

PDB	External Database	Details
Met 8	-	expression tag
Asp 9	-	expression tag
Ala 10	-	expression tag
Met 11	-	expression tag
Lys 12	-	expression tag
Arg 13	-	expression tag
Gly 14	-	expression tag
Leu 15	-	expression tag
Cys 16	-	expression tag
Cys 17	-	expression tag
Val 18	-	expression tag
Leu 19	-	expression tag
Leu 20	-	expression tag
Leu 21	-	expression tag
Cys 22	-	expression tag
Gly 23	-	expression tag
Ala 24	-	expression tag
Val 25	-	expression tag
Phe 26	-	expression tag
Val 27	-	expression tag
Ser 28	-	expression tag
Pro 29	-	expression tag
Ser 30	-	expression tag
Ala 31	-	expression tag
Ser 32	-	expression tag
Gly 224	-	expression tag
Ser 225	-	expression tag
Gly 226	-	expression tag
Ser 227	-	expression tag
Gly 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag
His 232	-	expression tag
His 233	-	expression tag
His 234	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	164672.2
Branched	Number of molecules	1
	Total formula weight	1073.0
Non-Polymers*	Number of molecules	8
	Total formula weight	1769.7
All*	Total formula weight	167514.8

*Water molecules are not included.