6C3O

Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, B, D)	ATP-sensitive inward rectifier potassium channel 11	polymer	406	45144.4	4	UniProt (Q14654) Pfam (PF01007) Pfam (PF17655)	Homo sapiens (Human)	IKATP,Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11
2	E, F, G, H (E, H, G, F)	ATP-binding cassette sub-family C member 8	polymer	1581	177180.2	4	UniProt (Q09428) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (Human)	Sulfonylurea receptor 1
3	AA, EA, I, M, N... (G, F, A, C, B...)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (ATP)
4	J, K, L (A)	POTASSIUM ION	non-polymer		39.1	3	Chemie (K)
5	BA, P, T, X (F, E, H, G)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	4	Chemie (ADP)
6	CA, DA, Q, R, U... (F, E, H, G)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)

Sequence modifications

A, C, B, D: 1 - 390 (UniProt: Q14654)

PDB	External Database	Details
Ser -5	-	expression tag
Ala -4	-	expression tag
Ser -3	-	expression tag
Ala -2	-	expression tag
Ser -1	-	expression tag
Ala 0	-	expression tag
Ser 391	-	expression tag
Asn 392	-	expression tag
Ser 393	-	expression tag
Leu 394	-	expression tag
Glu 395	-	expression tag
Val 396	-	expression tag
Leu 397	-	expression tag
Phe 398	-	expression tag
Gln 399	-	expression tag
Gly 400	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	889298.3
Non-Polymers*	Number of molecules	23
	Total formula weight	6078.0
All*	Total formula weight	895376.3

*Water molecules are not included.