6C3O

Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005242	molecular_function	inward rectifier potassium channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006006	biological_process	glucose metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008282	cellular_component	inward rectifying potassium channel
A	0009410	biological_process	response to xenobiotic stimulus
A	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
A	0016020	cellular_component	membrane
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0030315	cellular_component	T-tubule
A	0030506	molecular_function	ankyrin binding
A	0030955	molecular_function	potassium ion binding
A	0032991	cellular_component	protein-containing complex
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0042391	biological_process	regulation of membrane potential
A	0044325	molecular_function	transmembrane transporter binding
A	0046676	biological_process	negative regulation of insulin secretion
A	0046872	molecular_function	metal ion binding
A	0050796	biological_process	regulation of insulin secretion
A	0050877	biological_process	nervous system process
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098659	biological_process	inorganic cation import across plasma membrane
A	0099505	biological_process	regulation of presynaptic membrane potential
A	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
A	1990573	biological_process	potassium ion import across plasma membrane
B	0000166	molecular_function	nucleotide binding
B	0005242	molecular_function	inward rectifier potassium channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006006	biological_process	glucose metabolic process
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008282	cellular_component	inward rectifying potassium channel
B	0009410	biological_process	response to xenobiotic stimulus
B	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
B	0016020	cellular_component	membrane
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0030315	cellular_component	T-tubule
B	0030506	molecular_function	ankyrin binding
B	0030955	molecular_function	potassium ion binding
B	0032991	cellular_component	protein-containing complex
B	0033198	biological_process	response to ATP
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0042391	biological_process	regulation of membrane potential
B	0044325	molecular_function	transmembrane transporter binding
B	0046676	biological_process	negative regulation of insulin secretion
B	0046872	molecular_function	metal ion binding
B	0050796	biological_process	regulation of insulin secretion
B	0050877	biological_process	nervous system process
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
B	0098659	biological_process	inorganic cation import across plasma membrane
B	0099505	biological_process	regulation of presynaptic membrane potential
B	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
B	1990573	biological_process	potassium ion import across plasma membrane
C	0000166	molecular_function	nucleotide binding
C	0005242	molecular_function	inward rectifier potassium channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006006	biological_process	glucose metabolic process
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008282	cellular_component	inward rectifying potassium channel
C	0009410	biological_process	response to xenobiotic stimulus
C	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
C	0016020	cellular_component	membrane
C	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
C	0030315	cellular_component	T-tubule
C	0030506	molecular_function	ankyrin binding
C	0030955	molecular_function	potassium ion binding
C	0032991	cellular_component	protein-containing complex
C	0033198	biological_process	response to ATP
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0042391	biological_process	regulation of membrane potential
C	0044325	molecular_function	transmembrane transporter binding
C	0046676	biological_process	negative regulation of insulin secretion
C	0046872	molecular_function	metal ion binding
C	0050796	biological_process	regulation of insulin secretion
C	0050877	biological_process	nervous system process
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
C	0098659	biological_process	inorganic cation import across plasma membrane
C	0099505	biological_process	regulation of presynaptic membrane potential
C	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
C	1990573	biological_process	potassium ion import across plasma membrane
D	0000166	molecular_function	nucleotide binding
D	0005242	molecular_function	inward rectifier potassium channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006006	biological_process	glucose metabolic process
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008282	cellular_component	inward rectifying potassium channel
D	0009410	biological_process	response to xenobiotic stimulus
D	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
D	0016020	cellular_component	membrane
D	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
D	0030315	cellular_component	T-tubule
D	0030506	molecular_function	ankyrin binding
D	0030955	molecular_function	potassium ion binding
D	0032991	cellular_component	protein-containing complex
D	0033198	biological_process	response to ATP
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0042391	biological_process	regulation of membrane potential
D	0044325	molecular_function	transmembrane transporter binding
D	0046676	biological_process	negative regulation of insulin secretion
D	0046872	molecular_function	metal ion binding
D	0050796	biological_process	regulation of insulin secretion
D	0050877	biological_process	nervous system process
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport
D	0098659	biological_process	inorganic cation import across plasma membrane
D	0099505	biological_process	regulation of presynaptic membrane potential
D	0099508	molecular_function	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
D	1990573	biological_process	potassium ion import across plasma membrane
E	0000166	molecular_function	nucleotide binding
E	0001678	biological_process	intracellular glucose homeostasis
E	0005267	molecular_function	potassium channel activity
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006813	biological_process	potassium ion transport
E	0007565	biological_process	female pregnancy
E	0007613	biological_process	memory
E	0008281	molecular_function	sulfonylurea receptor activity
E	0008282	cellular_component	inward rectifying potassium channel
E	0008542	biological_process	visual learning
E	0009268	biological_process	response to pH
E	0009410	biological_process	response to xenobiotic stimulus
E	0010043	biological_process	response to zinc ion
E	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
E	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
E	0016020	cellular_component	membrane
E	0016525	biological_process	negative regulation of angiogenesis
E	0016887	molecular_function	ATP hydrolysis activity
E	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
E	0030672	cellular_component	synaptic vesicle membrane
E	0031004	cellular_component	potassium ion-transporting ATPase complex
E	0032496	biological_process	response to lipopolysaccharide
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0032868	biological_process	response to insulin
E	0032991	cellular_component	protein-containing complex
E	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
E	0042383	cellular_component	sarcolemma
E	0042734	cellular_component	presynaptic membrane
E	0043268	biological_process	positive regulation of potassium ion transport
E	0043531	molecular_function	ADP binding
E	0044325	molecular_function	transmembrane transporter binding
E	0046676	biological_process	negative regulation of insulin secretion
E	0046872	molecular_function	metal ion binding
E	0050768	biological_process	negative regulation of neurogenesis
E	0050796	biological_process	regulation of insulin secretion
E	0055085	biological_process	transmembrane transport
E	0060253	biological_process	negative regulation of glial cell proliferation
E	0061855	biological_process	negative regulation of neuroblast migration
E	0071805	biological_process	potassium ion transmembrane transport
E	0140359	molecular_function	ABC-type transporter activity
E	1900721	biological_process	positive regulation of uterine smooth muscle relaxation
E	1905075	biological_process	positive regulation of tight junction disassembly
E	1905604	biological_process	negative regulation of blood-brain barrier permeability
E	1990573	biological_process	potassium ion import across plasma membrane
F	0000166	molecular_function	nucleotide binding
F	0001678	biological_process	intracellular glucose homeostasis
F	0005267	molecular_function	potassium channel activity
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006813	biological_process	potassium ion transport
F	0007565	biological_process	female pregnancy
F	0007613	biological_process	memory
F	0008281	molecular_function	sulfonylurea receptor activity
F	0008282	cellular_component	inward rectifying potassium channel
F	0008542	biological_process	visual learning
F	0009268	biological_process	response to pH
F	0009410	biological_process	response to xenobiotic stimulus
F	0010043	biological_process	response to zinc ion
F	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
F	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
F	0016020	cellular_component	membrane
F	0016525	biological_process	negative regulation of angiogenesis
F	0016887	molecular_function	ATP hydrolysis activity
F	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
F	0030672	cellular_component	synaptic vesicle membrane
F	0031004	cellular_component	potassium ion-transporting ATPase complex
F	0032496	biological_process	response to lipopolysaccharide
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0032868	biological_process	response to insulin
F	0032991	cellular_component	protein-containing complex
F	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
F	0042383	cellular_component	sarcolemma
F	0042734	cellular_component	presynaptic membrane
F	0043268	biological_process	positive regulation of potassium ion transport
F	0043531	molecular_function	ADP binding
F	0044325	molecular_function	transmembrane transporter binding
F	0046676	biological_process	negative regulation of insulin secretion
F	0046872	molecular_function	metal ion binding
F	0050768	biological_process	negative regulation of neurogenesis
F	0050796	biological_process	regulation of insulin secretion
F	0055085	biological_process	transmembrane transport
F	0060253	biological_process	negative regulation of glial cell proliferation
F	0061855	biological_process	negative regulation of neuroblast migration
F	0071805	biological_process	potassium ion transmembrane transport
F	0140359	molecular_function	ABC-type transporter activity
F	1900721	biological_process	positive regulation of uterine smooth muscle relaxation
F	1905075	biological_process	positive regulation of tight junction disassembly
F	1905604	biological_process	negative regulation of blood-brain barrier permeability
F	1990573	biological_process	potassium ion import across plasma membrane
G	0000166	molecular_function	nucleotide binding
G	0001678	biological_process	intracellular glucose homeostasis
G	0005267	molecular_function	potassium channel activity
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006813	biological_process	potassium ion transport
G	0007565	biological_process	female pregnancy
G	0007613	biological_process	memory
G	0008281	molecular_function	sulfonylurea receptor activity
G	0008282	cellular_component	inward rectifying potassium channel
G	0008542	biological_process	visual learning
G	0009268	biological_process	response to pH
G	0009410	biological_process	response to xenobiotic stimulus
G	0010043	biological_process	response to zinc ion
G	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
G	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
G	0016020	cellular_component	membrane
G	0016525	biological_process	negative regulation of angiogenesis
G	0016887	molecular_function	ATP hydrolysis activity
G	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
G	0030672	cellular_component	synaptic vesicle membrane
G	0031004	cellular_component	potassium ion-transporting ATPase complex
G	0032496	biological_process	response to lipopolysaccharide
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0032868	biological_process	response to insulin
G	0032991	cellular_component	protein-containing complex
G	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
G	0042383	cellular_component	sarcolemma
G	0042734	cellular_component	presynaptic membrane
G	0043268	biological_process	positive regulation of potassium ion transport
G	0043531	molecular_function	ADP binding
G	0044325	molecular_function	transmembrane transporter binding
G	0046676	biological_process	negative regulation of insulin secretion
G	0046872	molecular_function	metal ion binding
G	0050768	biological_process	negative regulation of neurogenesis
G	0050796	biological_process	regulation of insulin secretion
G	0055085	biological_process	transmembrane transport
G	0060253	biological_process	negative regulation of glial cell proliferation
G	0061855	biological_process	negative regulation of neuroblast migration
G	0071805	biological_process	potassium ion transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity
G	1900721	biological_process	positive regulation of uterine smooth muscle relaxation
G	1905075	biological_process	positive regulation of tight junction disassembly
G	1905604	biological_process	negative regulation of blood-brain barrier permeability
G	1990573	biological_process	potassium ion import across plasma membrane
H	0000166	molecular_function	nucleotide binding
H	0001678	biological_process	intracellular glucose homeostasis
H	0005267	molecular_function	potassium channel activity
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006813	biological_process	potassium ion transport
H	0007565	biological_process	female pregnancy
H	0007613	biological_process	memory
H	0008281	molecular_function	sulfonylurea receptor activity
H	0008282	cellular_component	inward rectifying potassium channel
H	0008542	biological_process	visual learning
H	0009268	biological_process	response to pH
H	0009410	biological_process	response to xenobiotic stimulus
H	0010043	biological_process	response to zinc ion
H	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
H	0015272	molecular_function	ATP-activated inward rectifier potassium channel activity
H	0016020	cellular_component	membrane
H	0016525	biological_process	negative regulation of angiogenesis
H	0016887	molecular_function	ATP hydrolysis activity
H	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
H	0030672	cellular_component	synaptic vesicle membrane
H	0031004	cellular_component	potassium ion-transporting ATPase complex
H	0032496	biological_process	response to lipopolysaccharide
H	0032760	biological_process	positive regulation of tumor necrosis factor production
H	0032868	biological_process	response to insulin
H	0032991	cellular_component	protein-containing complex
H	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
H	0042383	cellular_component	sarcolemma
H	0042734	cellular_component	presynaptic membrane
H	0043268	biological_process	positive regulation of potassium ion transport
H	0043531	molecular_function	ADP binding
H	0044325	molecular_function	transmembrane transporter binding
H	0046676	biological_process	negative regulation of insulin secretion
H	0046872	molecular_function	metal ion binding
H	0050768	biological_process	negative regulation of neurogenesis
H	0050796	biological_process	regulation of insulin secretion
H	0055085	biological_process	transmembrane transport
H	0060253	biological_process	negative regulation of glial cell proliferation
H	0061855	biological_process	negative regulation of neuroblast migration
H	0071805	biological_process	potassium ion transmembrane transport
H	0140359	molecular_function	ABC-type transporter activity
H	1900721	biological_process	positive regulation of uterine smooth muscle relaxation
H	1905075	biological_process	positive regulation of tight junction disassembly
H	1905604	biological_process	negative regulation of blood-brain barrier permeability
H	1990573	biological_process	potassium ion import across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue ATP A 501

Chain	Residue
A	PHE183
A	LYS185
A	TYR330
A	SER331
A	GLY334
B	ASN48
B	ILE49
B	ARG50
B	GLU51

---

site_id	AC2
Number of Residues	7
Details	binding site for residue K A 502

Chain	Residue
A	PHE133
A	GLY134
B	PHE133
B	GLY134
C	PHE133
D	PHE133
D	GLY134

---

site_id	AC3
Number of Residues	8
Details	binding site for residue K A 503

Chain	Residue
A	ILE131
A	GLY132
B	ILE131
B	GLY132
C	ILE131
C	GLY132
D	ILE131
D	GLY132

---

site_id	AC4
Number of Residues	4
Details	binding site for residue K A 504

Chain	Residue
A	THR130
B	THR130
C	THR130
D	THR130

---

site_id	AC5
Number of Residues	11
Details	binding site for residue ATP C 501

Chain	Residue
C	ILE182
C	PHE183
C	LYS185
C	TYR330
C	SER331
C	LYS332
C	PHE333
D	ASN48
D	ILE49
D	ARG50
D	GLU51

---

site_id	AC6
Number of Residues	10
Details	binding site for residue ATP B 501

Chain	Residue
B	PHE183
B	LYS185
B	TYR330
B	SER331
B	LYS332
B	PHE333
C	ASN48
C	ILE49
C	ARG50
C	GLU51

---

site_id	AC7
Number of Residues	11
Details	binding site for residue ATP D 501

Chain	Residue
A	ASN48
A	ILE49
A	ARG50
A	GLU51
D	ILE182
D	PHE183
D	LYS185
D	TYR330
D	SER331
D	LYS332
D	PHE333

---

site_id	AC8
Number of Residues	10
Details	binding site for residue ADP E 2001

Chain	Residue
E	ARG1110
E	TYR1353
E	THR1380
E	GLY1381
E	SER1382
E	GLY1383
E	LYS1384
E	SER1385
E	SER1386
E	MG2003

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MG E 2002

Chain	Residue
E	SER720
E	GLN774
E	SER1482
E	ATP2004

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG E 2003

Chain	Residue
E	SER1385
E	ADP2001

---

site_id	AD2
Number of Residues	16
Details	binding site for residue ATP E 2004

Chain	Residue
E	SER408
E	MET409
E	TRP688
E	VAL715
E	GLY716
E	CYS717
E	GLY718
E	LYS719
E	SER720
E	SER721
E	GLN774
E	ASP854
E	PHE1481
E	SER1482
E	GLY1484
E	MG2002

---

site_id	AD3
Number of Residues	10
Details	binding site for residue ADP H 2001

Chain	Residue
H	SER1385
H	SER1386
H	MG2003
H	ARG1110
H	TYR1353
H	THR1380
H	GLY1381
H	SER1382
H	GLY1383
H	LYS1384

---

site_id	AD4
Number of Residues	4
Details	binding site for residue MG H 2002

Chain	Residue
H	SER720
H	GLN774
H	SER1482
H	ATP2004

---

site_id	AD5
Number of Residues	2
Details	binding site for residue MG H 2003

Chain	Residue
H	SER1385
H	ADP2001

---

site_id	AD6
Number of Residues	16
Details	binding site for residue ATP H 2004

Chain	Residue
H	SER408
H	MET409
H	TRP688
H	VAL715
H	GLY716
H	CYS717
H	GLY718
H	LYS719
H	SER720
H	SER721
H	GLN774
H	ASP854
H	PHE1481
H	SER1482
H	GLY1484
H	MG2002

---

site_id	AD7
Number of Residues	10
Details	binding site for residue ADP G 2001

Chain	Residue
G	ARG1110
G	TYR1353
G	THR1380
G	GLY1381
G	SER1382
G	GLY1383
G	LYS1384
G	SER1385
G	SER1386
G	MG2003

---

site_id	AD8
Number of Residues	4
Details	binding site for residue MG G 2002

Chain	Residue
G	SER720
G	GLN774
G	SER1482
G	ATP2004

---

site_id	AD9
Number of Residues	2
Details	binding site for residue MG G 2003

Chain	Residue
G	SER1385
G	ADP2001

---

site_id	AE1
Number of Residues	16
Details	binding site for residue ATP G 2004

Chain	Residue
G	SER408
G	MET409
G	TRP688
G	VAL715
G	GLY716
G	CYS717
G	GLY718
G	LYS719
G	SER720
G	SER721
G	GLN774
G	ASP854
G	PHE1481
G	SER1482
G	GLY1484
G	MG2002

---

site_id	AE2
Number of Residues	10
Details	binding site for residue ADP F 2001

Chain	Residue
F	ARG1110
F	TYR1353
F	THR1380
F	GLY1381
F	SER1382
F	GLY1383
F	LYS1384
F	SER1385
F	SER1386
F	MG2003

---

site_id	AE3
Number of Residues	4
Details	binding site for residue MG F 2002

Chain	Residue
F	SER720
F	GLN774
F	SER1482
F	ATP2004

---

site_id	AE4
Number of Residues	2
Details	binding site for residue MG F 2003

Chain	Residue
F	SER1385
F	ADP2001

---

site_id	AE5
Number of Residues	16
Details	binding site for residue ATP F 2004

Chain	Residue
F	SER408
F	MET409
F	TRP688
F	VAL715
F	GLY716
F	CYS717
F	GLY718
F	LYS719
F	SER720
F	SER721
F	GLN774
F	ASP854
F	PHE1481
F	SER1482
F	GLY1484
F	MG2002

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRISVARAL

Chain	Residue	Details
E	LEU829-LEU843
E	PHE1481-PHE1495

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=M1","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	124
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	Intramembrane: {"description":"Discontinuously helical; Pore-forming","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=M2","evidences":[{"source":"PubMed","id":"34815345","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P70673","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAPK1","evidences":[{"source":"PubMed","id":"18280666","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	208
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2236
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	64
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	936
Details	Domain: {"description":"ABC transporter 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29286281","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6C3P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"UniProtKB","id":"Q09427","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---