6C1S

Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	polymer	971	111268.8	1	UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB	Homo sapiens (Human)	PtdIns-3-kinase subunit gamma,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma,p110gamma,Phosphoinositide-3-kinase catalytic gamma polypeptide,Serine/threonine protein kinase PIK3CG,p120-PI3K
2	A	{4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile	non-polymer		376.4	1	Chemie (EFV)
3	A	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4		water	water		18.0	151	Chemie (HOH)

Sequence modifications

A: 144 - 1102 (UniProt: P48736)

PDB	External Database	Details
Met 140	-	expression tag
Pro 141	-	expression tag
Met 142	-	expression tag
Ala 143	-	expression tag
Leu 1103	-	expression tag
Glu 1104	-	expression tag
His 1105	-	expression tag
His 1106	-	expression tag
His 1107	-	expression tag
His 1108	-	expression tag
His 1109	-	expression tag
His 1110	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	111268.8
Non-Polymers*	Number of molecules	5
	Total formula weight	760.6
All*	Total formula weight	112029.4

*Water molecules are not included.