6C1O
FGFR1 kinase domain complexed with FIIN-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 1 | polymer | 311 | 35353.6 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
2 | A, B | N-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamide | non-polymer | 656.6 | 2 | Chemie (MK9) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
4 | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Gly 455 | - | expression tag |
Ala 456 | - | expression tag |
Met 457 | - | expression tag |
Ser 458 | - | expression tag |
Ala 488 | Cys 486 | engineered mutation |
Ser 584 | Cys 582 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70707.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 1409.3 | |
All* | Total formula weight | 72116.5 |