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6C1O

FGFR1 kinase domain complexed with FIIN-1

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BFibroblast growth factor receptor 1polymer31135353.62UniProt (P11362)
Pfam (PF07714)
In PDB
Homo sapiens (Human)FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr
2A, BN-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamidenon-polymer656.62Chemie (MK9)
3ASULFATE IONnon-polymer96.11Chemie (SO4)
4waterwater18.014Chemie (HOH)
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
PDBExternal DatabaseDetails
Gly 455-expression tag
Ala 456-expression tag
Met 457-expression tag
Ser 458-expression tag
Ala 488Cys 486engineered mutation
Ser 584Cys 582engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70707.2
Non-Polymers*Number of molecules3
Total formula weight1409.3
All*Total formula weight72116.5
*Water molecules are not included.

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PDB entries from 2024-09-18

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