6C09

Ternary crystal structure of the 3C8 TCR-CD1c-monoacylglycerol complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	T-cell surface glycoprotein CD1c	polymer	287	32283.1	1	UniProt (P29017) Pfam (PF16497) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	B	Beta-2-microglobulin	polymer	108	12646.2	1	UniProt (P61769) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	C	3C8 T cell receptor alpha-chain	polymer	205	22947.7	1		Homo sapiens
4	D	3C8 T cell receptor beta-chain	polymer	247	27587.6	1		Homo sapiens
5	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	A	(2R)-2,3-dihydroxypropyl hexadecanoate	non-polymer		330.5	1	Chemie (EKG)
7	A	DECANE	non-polymer		142.3	2	Chemie (D10)
8	A, D	POTASSIUM ION	non-polymer		39.1	3	Chemie (K)
9	C	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
10	C	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
11		water	water		18.0	13	Chemie (HOH)

Sequence modifications

A: 1 - 279 (UniProt: P29017)

PDB	External Database	Details
Glu -2	-	expression tag
Thr -1	-	expression tag
Gly 0	-	expression tag
Ser 280	-	expression tag
Leu 281	-	expression tag
Val 282	-	expression tag
Pro 283	-	expression tag
Arg 284	-	expression tag

B: 1 - 99 (UniProt: P61769)

PDB	External Database	Details
Glu -2	-	expression tag
Thr -1	-	expression tag
Gly 0	-	expression tag
Gly 100	-	expression tag
Ser 101	-	expression tag
Leu 102	-	expression tag
Val 103	-	expression tag
Pro 104	-	expression tag
Arg 105	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	95464.5
Non-Polymers*	Number of molecules	11
	Total formula weight	1245.9
All*	Total formula weight	96710.4

*Water molecules are not included.