6BWV

Crystal Structure of the 4-1BB/4-1BBL Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tumor necrosis factor ligand superfamily member 9	polymer	156	16438.7	2	UniProt (P41273) Pfam (PF00229)	Homo sapiens (Human)	4-1BB ligand,4-1BBL
2	C, D (D, E)	Tumor necrosis factor receptor superfamily member 9	polymer	141	15118.0	2	UniProt (Q07011) Pfam (PF00020)	Homo sapiens (Human)	4-1BB ligand receptor,CDw137,T-cell antigen 4-1BB homolog,T-cell antigen ILA
3	E (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
4	F, G, H, I (A, B, D, E)	water	water		18.0	45	Chemie (HOH)

Sequence modifications

A, B: 89 - 242 (UniProt: P41273)

PDB	External Database	Details
Gly 87	-	expression tag
Ser 88	-	expression tag

D, E: 24 - 160 (UniProt: Q07011)

PDB	External Database	Details
Ser 121	Cys 121	engineered mutation
Asp 138	Asn 138	engineered mutation
Gln 149	Asn 149	engineered mutation
Gly 161	-	expression tag
Ser 162	-	expression tag
Leu 163	-	expression tag
Gly 164	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	63113.5
Non-Polymers*	Number of molecules	1
	Total formula weight	106.1
All*	Total formula weight	63219.6

*Water molecules are not included.