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6BVI

Ras:SOS:Ras in complex with a small molecule activator

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AGTPase HRaspolymer16718856.11UniProt (P01112)
Pfam (PF00071)
In PDB
Homo sapiens (Human)H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
2BSon of sevenless homolog 1polymer48256589.81UniProt (Q07889)
Pfam (PF00618)
Pfam (PF00617)
In PDB
Homo sapiens (Human)SOS-1
3CGTPase HRaspolymer16718932.21UniProt (P01112)
Pfam (PF00071)
In PDB
Homo sapiens (Human)H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
4APHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTERnon-polymer522.21Chemie (GNP)
5AMAGNESIUM IONnon-polymer24.31Chemie (MG)
6B6-chloro-N-{1-[(5-chloro-1H-indol-3-yl)methyl]piperidin-4-yl}-L-tryptophanamidenon-polymer484.41Chemie (EC4)
7B, CFORMIC ACIDnon-polymer46.06Chemie (FMT)
8BGLYCEROLnon-polymer92.12Chemie (GOL)
9CSODIUM IONnon-polymer23.01Chemie (NA)
10waterwater18.01161Chemie (HOH)
Sequence modifications
A: 1 - 166 (UniProt: P01112)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ala 64Tyr 64engineered mutation
B: 566 - 1046 (UniProt: Q07889)
PDBExternal DatabaseDetails
Gly 565-expression tag
C: 1 - 166 (UniProt: P01112)
PDBExternal DatabaseDetails
Gly 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight94378.2
Non-Polymers*Number of molecules12
Total formula weight1514.3
All*Total formula weight95892.4
*Water molecules are not included.

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PDB entries from 2024-03-27

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