6BVI
Ras:SOS:Ras in complex with a small molecule activator
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue GNP A 201 |
| Chain | Residue |
| A | GLY12 |
| A | ASP30 |
| A | GLU31 |
| A | TYR32 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | GLN61 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | GLY13 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH318 |
| A | HOH347 |
| A | HOH352 |
| A | HOH371 |
| A | HOH386 |
| A | VAL14 |
| A | HOH398 |
| A | HOH427 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | GNP201 |
| A | HOH318 |
| A | HOH352 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue EC4 B 2001 |
| Chain | Residue |
| B | MET878 |
| B | ASN879 |
| B | TYR884 |
| B | PHE890 |
| B | LYS898 |
| B | LEU901 |
| B | GLU902 |
| B | HOH2227 |
| B | HOH2502 |
| B | HOH2560 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 2002 |
| Chain | Residue |
| B | GLN566 |
| B | MET567 |
| B | HIS616 |
| B | MET617 |
| B | HOH2169 |
| B | HOH2322 |
| B | HOH2336 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 2003 |
| Chain | Residue |
| A | ARG128 |
| B | ARG767 |
| B | PRO768 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 2004 |
| Chain | Residue |
| A | GLU37 |
| A | MET67 |
| A | GLN70 |
| B | ALA619 |
| B | ARG688 |
| B | HOH2148 |
| B | HOH2260 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 2005 |
| Chain | Residue |
| B | GLU611 |
| B | TYR615 |
| B | HIS616 |
| B | ARG647 |
| B | TYR681 |
| B | HOH2273 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue FMT B 2006 |
| Chain | Residue |
| B | TYR1031 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2007 |
| Chain | Residue |
| B | SER793 |
| B | ASP794 |
| B | PRO978 |
| B | TYR979 |
| B | HOH2275 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2008 |
| Chain | Residue |
| B | ARG786 |
| B | GLU864 |
| B | VAL1040 |
| B | HOH2113 |
| B | HOH2215 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue FMT C 201 |
| Chain | Residue |
| B | LEU938 |
| C | LYS16 |
| C | SER17 |
| C | ALA59 |
| C | HOH303 |
| C | HOH400 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 202 |
| Chain | Residue |
| C | ASN85 |
| C | ASN86 |
| C | THR87 |
| C | THR124 |
| C | HOH476 |
| C | HOH477 |
Functional Information from PROSITE/UniProt
| site_id | PS00720 |
| Number of Residues | 34 |
| Details | RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK |
| Chain | Residue | Details |
| B | VAL927-LYS960 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 144 |
| Details | Domain: {"description":"N-terminal Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00135","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 239 |
| Details | Domain: {"description":"Ras-GEF","evidences":[{"source":"PROSITE-ProRule","id":"PRU00168","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
