6BSJ
Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | REVERSE TRANSCRIPTASE P66 SUBUNIT | polymer | 558 | 64126.4 | 1 | UniProt (Q74085) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) UniProt (by SIFTS) (P04585) In PDB | Human immunodeficiency virus 1 | |
| 2 | B | REVERSE TRANSCRIPTASE P51 SUBUNIT | polymer | 441 | 51384.0 | 1 | UniProt (A0A076Q3N8) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) UniProt (by SIFTS) (P04585) In PDB | Human immunodeficiency virus 1 | |
| 3 | D | DNA (5'-D(*GP*TP*AP*TP*GP*CP*CP*TP*AP*TP*AP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3') | polymer | 23 | 7077.6 | 1 | Homo sapiens | ||
| 4 | R | RNA (25-MER) | polymer | 25 | 7903.8 | 1 | Homo sapiens | ||
| 5 | A | (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE | non-polymer | 315.7 | 1 | Chemie (EFZ) | |||
| 6 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | A, D | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 8 | R | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 1 | Chemie (TAM) | |||
| 9 | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A: 1 - 557 (UniProt: Q74085)
B: 1 - 440 (UniProt: A0A076Q3N8)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Gly 68 | Ser 235 | conflict |
| Lys 83 | Arg 250 | conflict |
| Met 357 | Thr 524 | conflict |
| Val 411 | Ile 578 | conflict |
| Lys 461 | Arg 628 | conflict |
| His 483 | Tyr 650 | conflict |
| Gln 512 | Lys 679 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Gly 68 | Ser 235 | conflict |
| Lys 83 | Arg 250 | conflict |
| Val 411 | Ile 578 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130491.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 887.3 | |
| All* | Total formula weight | 131379.1 |
