6BSJ

Structure of HIV-1 RT complexed with an RNA/DNA hybrid sequence non-preferred for RNA hydrolysis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EFZ A 601

Chain	Residue
A	LYS101
A	LYS103
A	VAL179
A	TYR181
A	TYR188
A	GLY190
A	TRP229
A	LEU234
A	HIS235

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CA A 602

Chain	Residue
A	ASP443
A	GLY444
A	GLU478
A	ASP498

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL A 603

Chain	Residue
A	LYS20
A	PRO55
A	ASN57

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL A 604

Chain	Residue
A	PRO4
A	TRP212

---

site_id	AC5
Number of Residues	1
Details	binding site for residue GOL D 101

Chain	Residue
D	DT18

---

site_id	AC6
Number of Residues	2
Details	binding site for residue GOL D 102

Chain	Residue
D	DG21
D	DG22

---

site_id	AC7
Number of Residues	3
Details	binding site for residue TAM R 101

Chain	Residue
D	DG6
R	G22
R	G23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12206668","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 175

Chain

Residue

Details

---