6BRC
Crystal Structure of the Human CAMKK2B in complex with AP26113-analog (ALK-IN-1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Calcium/calmodulin-dependent protein kinase kinase 2 | polymer | 291 | 33127.3 | 2 | UniProt (Q96RR4) Pfam (PF00069) | Homo sapiens (Human) | CaMKK 2,Calcium/calmodulin-dependent protein kinase kinase beta,CaMKK beta |
| 2 | C, D (A, B) | 5-chloro-N~2~-{4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}-N~4~-[2-(dimethylphosphoryl)phenyl]pyrimidine-2,4-diamine | non-polymer | 529.0 | 2 | Chemie (E5J) | |||
| 3 | E (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A, B: 161 - 449 (UniProt: Q96RR4)
| PDB | External Database | Details |
|---|---|---|
| Ser 159 | - | expression tag |
| Met 160 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66254.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1081.0 | |
| All* | Total formula weight | 67335.5 |
