6BQH

Crystal structure of 5-HT2C in complex with ritanserin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	5-hydroxytryptamine receptor 2C,Soluble cytochrome b562	polymer	452	51310.1	1	UniProt (P28335) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361)	Homo sapiens (Human)	5-HTR2C,5-hydroxytryptamine receptor 1C,5-HT1C,Serotonin receptor 2C,Cytochrome b-562
2	B (A)	6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one	non-polymer		477.6	1	Chemie (E2J)
3	C, D, E, F, G... (A)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	6	Chemie (OLC)
4	I (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5	J, K (A)	OLEIC ACID	non-polymer		282.5	2	Chemie (OLA)
6	L (A)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

A: 40 - 245 (UniProt: P28335)

PDB	External Database	Details
Met 14	-	expression tag
Lys 15	-	expression tag
Thr 16	-	expression tag
Ile 17	-	expression tag
Ile 18	-	expression tag
Ala 19	-	expression tag
Leu 20	-	expression tag
Ser 21	-	expression tag
Tyr 22	-	expression tag
Ile 23	-	expression tag
Phe 24	-	expression tag
Cys 25	-	expression tag
Leu 26	-	expression tag
Val 27	-	expression tag
Phe 28	-	expression tag
Ala 29	-	expression tag
Asp 30	-	expression tag
Tyr 31	-	expression tag
Lys 32	-	expression tag
Asp 33	-	expression tag
Asp 34	-	expression tag
Asp 35	-	expression tag
Asp 36	-	expression tag
Gly 37	-	expression tag
Ala 38	-	expression tag
Pro 39	-	expression tag

A: 1001 - 1106 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	engineered mutation
Ile 1102	His 124	engineered mutation
Leu 1106	Arg 128	engineered mutation

A: 301 - 393 (UniProt: P28335)

PDB	External Database	Details
Asn 360	Cys 360	conflict
Gly 394	-	expression tag
Arg 395	-	expression tag
Pro 396	-	expression tag
Leu 397	-	expression tag
Glu 398	-	expression tag
Val 399	-	expression tag
Leu 400	-	expression tag
Phe 401	-	expression tag
Gln 402	-	expression tag
Gly 403	-	expression tag
Pro 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag
His 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	51310.1
Non-Polymers*	Number of molecules	10
	Total formula weight	3287.9
All*	Total formula weight	54597.9

*Water molecules are not included.