6BQH
Crystal structure of 5-HT2C in complex with ritanserin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | 5-hydroxytryptamine receptor 2C,Soluble cytochrome b562 | polymer | 452 | 51310.1 | 1 | UniProt (P28335) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | 5-HTR2C,5-hydroxytryptamine receptor 1C,5-HT1C,Serotonin receptor 2C,Cytochrome b-562 |
2 | A | 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one | non-polymer | 477.6 | 1 | Chemie (E2J) | |||
3 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 6 | Chemie (OLC) | |||
4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
5 | A | OLEIC ACID | non-polymer | 282.5 | 2 | Chemie (OLA) | |||
6 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 40 - 245 (UniProt: P28335)
A: 1001 - 1106 (UniProt: P0ABE7)
A: 301 - 393 (UniProt: P28335)
PDB | External Database | Details |
---|---|---|
Met 14 | - | expression tag |
Lys 15 | - | expression tag |
Thr 16 | - | expression tag |
Ile 17 | - | expression tag |
Ile 18 | - | expression tag |
Ala 19 | - | expression tag |
Leu 20 | - | expression tag |
Ser 21 | - | expression tag |
Tyr 22 | - | expression tag |
Ile 23 | - | expression tag |
Phe 24 | - | expression tag |
Cys 25 | - | expression tag |
Leu 26 | - | expression tag |
Val 27 | - | expression tag |
Phe 28 | - | expression tag |
Ala 29 | - | expression tag |
Asp 30 | - | expression tag |
Tyr 31 | - | expression tag |
Lys 32 | - | expression tag |
Asp 33 | - | expression tag |
Asp 34 | - | expression tag |
Asp 35 | - | expression tag |
Asp 36 | - | expression tag |
Gly 37 | - | expression tag |
Ala 38 | - | expression tag |
Pro 39 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Leu 1106 | Arg 128 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 360 | Cys 360 | conflict |
Gly 394 | - | expression tag |
Arg 395 | - | expression tag |
Pro 396 | - | expression tag |
Leu 397 | - | expression tag |
Glu 398 | - | expression tag |
Val 399 | - | expression tag |
Leu 400 | - | expression tag |
Phe 401 | - | expression tag |
Gln 402 | - | expression tag |
Gly 403 | - | expression tag |
Pro 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
His 407 | - | expression tag |
His 408 | - | expression tag |
His 409 | - | expression tag |
His 410 | - | expression tag |
His 411 | - | expression tag |
His 412 | - | expression tag |
His 413 | - | expression tag |
His 414 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 51310.1 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 3287.9 | |
All* | Total formula weight | 54597.9 |