6BQH

Crystal structure of 5-HT2C in complex with ritanserin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004993	molecular_function	G protein-coupled serotonin receptor activity
A	0005506	molecular_function	iron ion binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue E2J A 1201

Chain	Residue
A	TRP130
A	PHE223
A	PHE320
A	PHE327
A	PHE328
A	ASN351
A	VAL354
A	TYR358
A	HOH1301
A	ASP134
A	VAL135
A	SER138
A	THR139
A	ILE142
A	VAL215
A	GLY218
A	SER219

---

site_id	AC2
Number of Residues	4
Details	binding site for residue OLC A 1202

Chain	Residue
A	TRP55
A	LEU349
A	PHE353
A	OLC1203

---

site_id	AC3
Number of Residues	3
Details	binding site for residue OLC A 1203

Chain	Residue
A	LEU333
A	MET346
A	OLC1202

---

site_id	AC4
Number of Residues	4
Details	binding site for residue OLC A 1204

Chain	Residue
A	MET76
A	TYR382
A	ASN386
A	TYR387

---

site_id	AC5
Number of Residues	3
Details	binding site for residue OLC A 1206

Chain	Residue
A	THR228
A	ILE229
A	ILE232

---

site_id	AC6
Number of Residues	2
Details	binding site for residue OLC A 1207

Chain	Residue
A	CYS146
A	VAL221

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PEG A 1208

Chain	Residue
A	LEU370
A	PHE371
A	ARG376
A	ARG376
A	ARG377

---

site_id	AC8
Number of Residues	5
Details	binding site for residue OLA A 1210

Chain	Residue
A	TYR90
A	MET93
A	ILE97
A	ILE172
A	TRP179

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI

Chain	Residue	Details
A	ALA140-ILE156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TRANSMEM: Helical; Name=1 => ECO:0000250

Chain	Residue	Details
A	GLN53-VAL78

---

site_id	SWS_FT_FI2
Number of Residues	29
Details	TOPO_DOM: Cytoplasmic => ECO:0000250

Chain	Residue	Details
A	SER79-ASN89
A	ASP151-LYS170

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	TRANSMEM: Helical; Name=2 => ECO:0000250

Chain	Residue	Details
A	TYR90-SER110

---

site_id	SWS_FT_FI4
Number of Residues	49
Details	TOPO_DOM: Extracellular => ECO:0000250

Chain	Residue	Details
A	LEU111-CYS127
A	LEU194-ASN213
A	SER334-LYS348

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3 => ECO:0000250

Chain	Residue	Details
A	PRO128-LEU150

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4 => ECO:0000250

Chain	Residue	Details
A	ALA171-GLY193

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=5 => ECO:0000250

Chain	Residue	Details
A	PHE214-CYS235

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000250

Chain	Residue	Details
A	VAL312-LEU333

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	TRANSMEM: Helical; Name=7 => ECO:0000250

Chain	Residue	Details
A	LEU349-PHE371

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P41595

Chain	Residue	Details
A	ASP134
A	THR139
A	LEU209

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498

Chain	Residue	Details
A	ASN204

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

---