6BQH

Crystal structure of 5-HT2C in complex with ritanserin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004993	molecular_function	G protein-coupled serotonin receptor activity
A	0005506	molecular_function	iron ion binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue E2J A 1201

Chain	Residue
A	TRP130
A	PHE223
A	PHE320
A	PHE327
A	PHE328
A	ASN351
A	VAL354
A	TYR358
A	HOH1301
A	ASP134
A	VAL135
A	SER138
A	THR139
A	ILE142
A	VAL215
A	GLY218
A	SER219

---

site_id	AC2
Number of Residues	4
Details	binding site for residue OLC A 1202

Chain	Residue
A	TRP55
A	LEU349
A	PHE353
A	OLC1203

---

site_id	AC3
Number of Residues	3
Details	binding site for residue OLC A 1203

Chain	Residue
A	LEU333
A	MET346
A	OLC1202

---

site_id	AC4
Number of Residues	4
Details	binding site for residue OLC A 1204

Chain	Residue
A	MET76
A	TYR382
A	ASN386
A	TYR387

---

site_id	AC5
Number of Residues	3
Details	binding site for residue OLC A 1206

Chain	Residue
A	THR228
A	ILE229
A	ILE232

---

site_id	AC6
Number of Residues	2
Details	binding site for residue OLC A 1207

Chain	Residue
A	CYS146
A	VAL221

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PEG A 1208

Chain	Residue
A	LEU370
A	PHE371
A	ARG376
A	ARG376
A	ARG377

---

site_id	AC8
Number of Residues	5
Details	binding site for residue OLA A 1210

Chain	Residue
A	TYR90
A	MET93
A	ILE97
A	ILE172
A	TRP179

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI

Chain	Residue	Details
A	ALA140-ILE156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	49
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Motif: {"description":"DRY motif; important for ligand-induced conformation changes","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Motif: {"description":"NPxxY motif; important for ligand-induced conformation changes and signaling","evidences":[{"source":"UniProtKB","id":"P41595","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29398112","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQG","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---