6BOQ
Human APE1 substrate complex with an A/A mismatch adjacent the THF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA-(apurinic or apyrimidinic site) lyase | polymer | 318 | 35574.4 | 2 | UniProt (P27695) Pfam (PF03372) | Homo sapiens (Human) | APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1,APE-1,REF-1,Redox factor-1 |
| 2 | C (D) | 21-mer DNA | polymer | 21 | 6356.1 | 1 | synthetic construct | ||
| 3 | D (V) | 21-mer DNA | polymer | 21 | 6433.2 | 1 | synthetic construct | ||
| 4 | E, F, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | H, I, J, K (A, B, D, V) | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 318 (UniProt: P27695)
| PDB | External Database | Details |
|---|---|---|
| Ala 138 | Cys 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 83938.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 186.2 | |
| All* | Total formula weight | 84124.4 |
