6BOQ
Human APE1 substrate complex with an A/A mismatch adjacent the THF
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA-(apurinic or apyrimidinic site) lyase | polymer | 318 | 35574.4 | 2 | UniProt (P27695) Pfam (PF03372) In PDB | Homo sapiens (Human) | APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1,APE-1,REF-1,Redox factor-1 |
2 | D | 21-mer DNA | polymer | 21 | 6356.1 | 1 | synthetic construct | ||
3 | V | 21-mer DNA | polymer | 21 | 6433.2 | 1 | synthetic construct | ||
4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
5 | water | water | 18.0 | 219 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 318 (UniProt: P27695)
PDB | External Database | Details |
---|---|---|
Ala 138 | Cys 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 83938.2 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 186.2 | |
All* | Total formula weight | 84124.4 |