6BNT

Crystal structure of AP2 mu1 adaptin C-terminal domain with IRS-1 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	AP-2 complex subunit mu	polymer	315	35697.6	1	UniProt (Q96CW1) Pfam (PF00928) In PDB	Homo sapiens (Human)	AP-2 mu chain, Adaptin-mu2, Adaptor protein complex AP-2 subunit mu, Adaptor-related protein complex 2 subunit mu, Clathrin assembly protein complex 2 mu medium chain, Clathrin coat assembly protein AP50, Clathrin coat-associated protein AP50, HA2 50 kDa subunit, Plasma membrane adaptor AP-2 50 kDa protein
2	B	Insulin receptor substrate 1	polymer	15	1661.7	1	UniProt (P35568) In PDB	Homo sapiens (Human)	IRS-1
3		water	water		18.0	34	Chemie (HOH)

Sequence modifications

A: 160 - 435 (UniProt: Q96CW1)

PDB	External Database	Details
Met 121	-	expression tag
Gly 122	-	expression tag
Ser 123	-	expression tag
Ser 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
Ser 131	-	expression tag
Ser 132	-	expression tag
Gly 133	-	expression tag
Leu 134	-	expression tag
Val 135	-	expression tag
Pro 136	-	expression tag
Arg 137	-	expression tag
Gly 138	-	expression tag
Ser 139	-	expression tag
His 140	-	expression tag
Met 141	-	expression tag
Ala 142	-	expression tag
Ser 143	-	expression tag
Met 144	-	expression tag
Thr 145	-	expression tag
Gly 146	-	expression tag
Gly 147	-	expression tag
Gln 148	-	expression tag
Gln 149	-	expression tag
Met 150	-	expression tag
Gly 151	-	expression tag
Arg 152	-	expression tag
Gly 153	-	expression tag
Ser 154	-	expression tag
Glu 155	-	expression tag
Phe 156	-	expression tag
Gly 157	-	expression tag
Arg 158	-	expression tag
Pro 159	-	expression tag

B: 607 - 620 (UniProt: P35568)

PDB	External Database	Details
Cys 606	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	37359.3
All*	Total formula weight	37359.3

*Water molecules are not included.