6BKC

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3B

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Fab AR3B heavy chain	polymer	230	24035.2	1	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
2	B (L)	Fab AR3B light chain	polymer	215	23418.9	1	UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
3	C (E)	Polyprotein	polymer	189	20707.4	1	UniProt (B9V0E2) Pfam (PF01560)	Recombinant Hepatitis C virus HK6a/JFH-1
4	D, E, F, G (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	H, I, J (H, L, E)	water	water		18.0	47	Chemie (HOH)

Sequence modifications

H: 3 - 102 (PDB: 6BKC)
H: 103 - 216 (UniProt: P0DOX5)

PDB	External Database	Details
Gln 108	Leu 114	conflict
Gly 217	-	expression tag
Ser 218	-	expression tag

L: 1 - 105 (PDB: 6BKC)
L: 106 - 214 (UniProt: Q8TCD0)
E: 412 - 481 (UniProt: B9V0E2)

PDB	External Database	Details
Asp 470	Asn 448	engineered mutation

E: 486 - 585 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 482	-	linker
Ser 483	-	linker
Ser 484	-	linker
Gly 485	-	linker

E: 598 - 645 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 586	-	linker
Gly 587	-	linker
Pro 588	-	linker
Thr 589	-	linker
Asp 590	-	linker
Gly 591	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	68161.4
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	69046.2

*Water molecules are not included.