6BKB
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | H | Fab AR3A heavy chain | polymer | 232 | 24581.4 | 1 | UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
2 | E | Polyprotein | polymer | 189 | 20707.4 | 1 | UniProt (B9V0E2) Pfam (PF01560) In PDB | Recombinant Hepatitis C virus HK6a/JFH-1 | |
3 | L | Fab AR3A light chain | polymer | 214 | 23296.8 | 1 | UniProt (Q6PIL8) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
6 | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
H: 1 - 102 (PDB: 6BKB)
H: 103 - 216 (UniProt: P0DOX5)
E: 412 - 481 (UniProt: B9V0E2)
E: 486 - 568 (UniProt: B9V0E2)
E: 598 - 645 (UniProt: B9V0E2)
L: 1 - 104 (PDB: 6BKB)
L: 105 - 214 (UniProt: Q6PIL8)
H: 103 - 216 (UniProt: P0DOX5)
PDB | External Database | Details |
---|---|---|
Gly 217 | - | expression tag |
Ser 218 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp 448 | Asn 448 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 482 | - | linker |
Ser 483 | - | linker |
Ser 484 | - | linker |
Gly 485 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 572 | - | linker |
Gly 573 | - | linker |
Pro 582 | - | linker |
Thr 583 | - | linker |
Asp 584 | - | linker |
Gly 591 | - | linker |
L: 105 - 214 (UniProt: Q6PIL8)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 68585.6 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 69673.7 |