6BKB

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody AR3A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Fab AR3A heavy chain	polymer	232	24581.4	1	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	E	Polyprotein	polymer	189	20707.4	1	UniProt (B9V0E2) Pfam (PF01560) In PDB	Recombinant Hepatitis C virus HK6a/JFH-1
3	L	Fab AR3A light chain	polymer	214	23296.8	1	UniProt (Q6PIL8) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
6		water	water		18.0	15	Chemie (HOH)

Sequence modifications

H: 1 - 102 (PDB: 6BKB)
H: 103 - 216 (UniProt: P0DOX5)

PDB	External Database	Details
Gly 217	-	expression tag
Ser 218	-	expression tag

E: 412 - 481 (UniProt: B9V0E2)

PDB	External Database	Details
Asp 448	Asn 448	engineered mutation

E: 486 - 568 (UniProt: B9V0E2)

E: 598 - 645 (UniProt: B9V0E2)

L: 1 - 104 (PDB: 6BKB)
L: 105 - 214 (UniProt: Q6PIL8)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.