6BJD
Crystal Structure of Human Calpain-3 Protease Core in Complex with E-64
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Calpain-3 | polymer | 382 | 44456.2 | 4 | UniProt (P20807) Pfam (PF00648) | Homo sapiens (Human) | Calcium-activated neutral proteinase 3,CANP 3,Calpain L3,Calpain p94,Muscle-specific calcium-activated neutral protease 3,New calpain 1,nCL-1 |
| 2 | E, F, I, J, N... (A, B, C, D) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 3 | G, K, P, T (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | H, L, Q, U (A, B, C, D) | N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | non-polymer | 360.4 | 4 | Chemie (E64) | |||
| 5 | M (B) | sorbitol | non-polymer | 182.2 | 1 | Chemie (SOR) | |||
| 6 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 46 - 419 (UniProt: P20807)
| PDB | External Database | Details |
|---|---|---|
| Leu 420 | - | expression tag |
| Glu 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| His 426 | - | expression tag |
| His 427 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 177824.7 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2086.3 | |
| All* | Total formula weight | 179911.0 |
