6BHU

Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Multidrug resistance-associated protein 1	polymer	1659	183074.1	1	UniProt (Q8HXQ5) Pfam (PF00664) Pfam (PF00005) In PDB	Bos taurus (Bovine)	ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,LTC4 transporter
2	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
3	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A	CHOLESTEROL	non-polymer		386.7	3	Chemie (CLR)

Sequence modifications

A: 30 - 194 (PDB: 6BHU)
A: 194 - 1530 (UniProt: Q8HXQ5)

PDB	External Database	Details
Gln 1454	Glu 1454	engineered mutation
Ser 1531	-	expression tag
Asn 1532	-	expression tag
Ser 1533	-	expression tag
Leu 1534	-	expression tag
Glu 1535	-	expression tag
Val 1536	-	expression tag
Leu 1537	-	expression tag
Phe 1538	-	expression tag
Gln 1539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	183074.1
Non-Polymers*	Number of molecules	7
	Total formula weight	2222.9
All*	Total formula weight	185297.0

*Water molecules are not included.