6BHU
Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Multidrug resistance-associated protein 1 | polymer | 1659 | 183074.1 | 1 | UniProt (Q8HXQ5) Pfam (PF00664) Pfam (PF00005) | Bos taurus (Bovine) | ATP-binding cassette sub-family C member 1,Leukotriene C(4) transporter,LTC4 transporter |
| 2 | B, C (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F, G, H (A) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) |
Sequence modifications
A: 30 - 194 (PDB: 6BHU)
A: 194 - 1530 (UniProt: Q8HXQ5)
A: 194 - 1530 (UniProt: Q8HXQ5)
| PDB | External Database | Details |
|---|---|---|
| Gln 1454 | Glu 1454 | engineered mutation |
| Ser 1531 | - | expression tag |
| Asn 1532 | - | expression tag |
| Ser 1533 | - | expression tag |
| Leu 1534 | - | expression tag |
| Glu 1535 | - | expression tag |
| Val 1536 | - | expression tag |
| Leu 1537 | - | expression tag |
| Phe 1538 | - | expression tag |
| Gln 1539 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 183074.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2222.9 | |
| All* | Total formula weight | 185297.0 |
