6BGT

Structure of Trastuzumab Fab mutant in complex with Her2 extracellular domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Receptor tyrosine-protein kinase erbB-2	polymer	658	72499.5	1	UniProt (P04626) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843)	Homo sapiens (Human)	Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2
2	B (A)	Herceptin light chain mutant	polymer	214	23494.0	1	UniProt (Q7Z3Y4) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
3	C (B)	Herceptin heavy chain Fab fragment mutant	polymer	231	24703.5	1	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
4	D (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	E, F (C, A)	water	water		18.0	29	Chemie (HOH)

Sequence modifications

C: -21 - 630 (UniProt: P04626)

PDB	External Database	Details
His 631	-	expression tag
His 632	-	expression tag
His 633	-	expression tag
His 634	-	expression tag
His 635	-	expression tag
His 636	-	expression tag

A: 1 - 104 (PDB: 6BGT)
A: 105 - 214 (UniProt: Q7Z3Y4)
B: 1 - 109 (PDB: 6BGT)
B: 110 - 223 (UniProt: P0DOX5)

PDB	External Database	Details
Gly 224	-	expression tag
Ser 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag
His 231	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	120697.0
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	120918.2

*Water molecules are not included.