6BFT

Structure of Bevacizumab Fab mutant in complex with VEGF

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, L	Avastin Light Chain Fab fragment mutant	polymer	214	23528.0	2	UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	A, H	Avastin Heavy Chain Fab fragment mutant	polymer	231	24918.7	2	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	G, C	Vascular endothelial growth factor A	polymer	102	11933.7	2	UniProt (P15692) Pfam (PF00341) In PDB	Homo sapiens (Human)	VEGF-A, Vascular permeability factor, VPF
4	B, L	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	H	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
6		water	water		18.0	131	Chemie (HOH)

Sequence modifications

B, L: 1 - 104 (PDB: 6BFT)
B, L: 105 - 214 (UniProt: Q8TCD0)
A, H: 1 - 123 (PDB: 6BFT)
A, H: 124 - 231 (UniProt: P0DOX5)
G, C: 10 - 109 (UniProt: P15692)

PDB	External Database	Details
Gly 8	-	cloning artifact
Pro 9	-	cloning artifact

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.