6BFT
Structure of Bevacizumab Fab mutant in complex with VEGF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, L) | Avastin Light Chain Fab fragment mutant | polymer | 214 | 23528.0 | 2 | UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B, D (A, H) | Avastin Heavy Chain Fab fragment mutant | polymer | 231 | 24918.7 | 2 | UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | E, F (G, C) | Vascular endothelial growth factor A | polymer | 102 | 11933.7 | 2 | UniProt (P15692) Pfam (PF00341) | Homo sapiens (Human) | VEGF-A, Vascular permeability factor, VPF |
| 4 | G, H (B, L) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I, J (H) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
| 6 | K, L, M, N, O... (B, A, L, H, G...) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
B, L: 1 - 104 (PDB: 6BFT)
B, L: 105 - 214 (UniProt: Q8TCD0)
A, H: 1 - 123 (PDB: 6BFT)
A, H: 124 - 231 (UniProt: P0DOX5)
G, C: 10 - 109 (UniProt: P15692)
B, L: 105 - 214 (UniProt: Q8TCD0)
A, H: 1 - 123 (PDB: 6BFT)
A, H: 124 - 231 (UniProt: P0DOX5)
G, C: 10 - 109 (UniProt: P15692)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | cloning artifact |
| Pro 9 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 120760.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 582.6 | |
| All* | Total formula weight | 121343.3 |
