6BAA
Cryo-EM structure of the pancreatic beta-cell KATP channel bound to ATP and glibenclamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | ATP-sensitive inward rectifier potassium channel 11 | polymer | 390 | 43645.7 | 4 | UniProt (P70673) Pfam (PF01007) Pfam (PF17655) | Rattus norvegicus (Rat) | BIR,Inward rectifier K(+) channel Kir6.2,Potassium channel,inwardly rectifying subfamily J member 11 |
| 2 | E, F, G, H (E, F, G, H) | ATP-binding cassette sub-family C member 8 | polymer | 1582 | 177333.6 | 4 | UniProt (Q09427) Pfam (PF00664) Pfam (PF00005) | Cricetus cricetus (Black-bellied hamster) | Sulfonylurea receptor 1 |
| 3 | I, J, K, L (A, B, C, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 4 | M, N, O, P (E, F, G, H) | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide | non-polymer | 494.0 | 4 | Chemie (GBM) |
Sequence modifications
A, B, C, D: 1 - 390 (UniProt: P70673)
| PDB | External Database | Details |
|---|---|---|
| Pro 191 | Leu 191 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 883917.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4004.7 | |
| All* | Total formula weight | 887921.9 |
