6BA5
Potent and Selective Antitumor Activity of a T-Cell Engaging Bispecific Antibody Targeting a Membrane-Proximal Epitope of ROR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G | Variable domain of Light Chain, antibody R11 | polymer | 114 | 11894.1 | 4 | Homo sapiens | ||
| 2 | B, D, F, H | Variable domain Heavy chain, antibody R11 | polymer | 117 | 12665.9 | 4 | Homo sapiens | ||
| 3 | M, N, O, P | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | polymer | 82 | 9356.4 | 4 | UniProt (Q01973) Pfam (PF00051) In PDB | Homo sapiens (Human) | Neurotrophic tyrosine kinase,receptor-related 1 |
| 4 | water | water | 18.0 | 1364 | Chemie (HOH) |
Sequence modifications
M, N, O, P: 311 - 391 (UniProt: Q01973)
| PDB | External Database | Details |
|---|---|---|
| Met 310 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 135665.9 | |
| All* | Total formula weight | 135665.9 |
