6B88

E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Signal peptidase I	polymer	247	27736.3	2	UniProt (P00803) Pfam (PF10502)	Escherichia coli (strain K12)	SPase I,Leader peptidase I
2	C, E (A, B)	(8S,11S,14S)-14-{[(2S)-4-amino-2-{[2-(4-tert-butylphenyl)-4-methylpyrimidine-5-carbonyl]amino}butanoyl](methyl)amino}-3,18-bis(2-aminoethoxy)-N-[(2Z)-2-iminoethyl]-11-methyl-10,13-dioxo-9,12-diazatricyclo[13.3.1.1~2,6~]icosa-1(19),2(20),3,5,15,17-hexaene-8-carboxamide	non-polymer		892.1	2	Chemie (CZD)
3	D (B)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
4	F, G (A, B)	water	water		18.0	99	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55472.7
Non-Polymers*	Number of molecules	3
	Total formula weight	2022.4
All*	Total formula weight	57495.1

*Water molecules are not included.