6B88
E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0006465 | biological_process | signal peptide processing |
A | 0006508 | biological_process | proteolysis |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0016020 | cellular_component | membrane |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0006465 | biological_process | signal peptide processing |
B | 0006508 | biological_process | proteolysis |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | binding site for residue CZD A 401 |
Chain | Residue |
A | PRO83 |
A | ALA279 |
A | TRP300 |
A | TRP300 |
A | HOH522 |
B | LEU314 |
B | LEU316 |
A | PHE84 |
A | GLN85 |
A | PRO87 |
A | SER90 |
A | ASP142 |
A | TYR143 |
A | ILE144 |
A | LYS145 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue 1PE B 401 |
Chain | Residue |
A | TYR251 |
A | PRO254 |
A | TRP284 |
A | PHE286 |
B | GLU137 |
B | TYR251 |
B | GLN253 |
B | TRP284 |
B | HOH518 |
site_id | AC3 |
Number of Residues | 14 |
Details | binding site for residue CZD B 402 |
Chain | Residue |
A | LEU314 |
B | GLU82 |
B | PRO83 |
B | PHE84 |
B | GLN85 |
B | PRO87 |
B | SER90 |
B | ASP142 |
B | TYR143 |
B | ILE144 |
B | LYS145 |
B | ALA279 |
B | TRP300 |
B | TRP300 |
Functional Information from PROSITE/UniProt
site_id | PS00501 |
Number of Residues | 8 |
Details | SPASE_I_1 Signal peptidases I serine active site. SGSMMPTL |
Chain | Residue | Details |
A | SER88-LEU95 | |
site_id | PS00760 |
Number of Residues | 13 |
Details | SPASE_I_2 Signal peptidases I lysine active site. KRAVGlPGDkVtY |
Chain | Residue | Details |
A | LYS145-TYR157 | |
site_id | PS00761 |
Number of Residues | 14 |
Details | SPASE_I_3 Signal peptidases I signature 3. YFMMGDNRdnSadS |
Chain | Residue | Details |
A | TYR268-SER281 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 492 |
Details | TOPO_DOM: Periplasmic => ECO:0000305 |
Chain | Residue | Details |
A | ARG77-HIS323 | |
B | ARG77-HIS323 | |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: |
Chain | Residue | Details |
A | SER90 | |
A | LYS145 | |
B | SER90 | |
B | LYS145 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 635 |
Chain | Residue | Details |
A | SER88 | electrostatic stabiliser |
A | SER90 | nucleofuge, nucleophile, proton acceptor, proton donor |
A | LYS145 | proton acceptor, proton donor |
A | SER278 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 635 |
Chain | Residue | Details |
B | SER88 | electrostatic stabiliser |
B | SER90 | nucleofuge, nucleophile, proton acceptor, proton donor |
B | LYS145 | proton acceptor, proton donor |
B | SER278 | electrostatic stabiliser |