6B6U
Pyruvate Kinase M2 mutant - S437Y
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pyruvate kinase PKM | polymer | 525 | 57423.1 | 2 | UniProt (P14618) Pfam (PF00224) Pfam (PF02887) | Homo sapiens (Human) | Cytosolic thyroid hormone-binding protein,CTHBP,Opa-interacting protein 3,OIP-3,Pyruvate kinase 2/3,Pyruvate kinase muscle isozyme,Thyroid hormone-binding protein 1,THBP1,Tumor M2-PK,p58 |
| 2 | C, L (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, M (A, B) | OXALATE ION | non-polymer | 88.0 | 2 | Chemie (OXL) | |||
| 4 | E, N (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | F, O (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | G, H, I, P, Q... (A, B) | THIOCYANATE ION | non-polymer | 58.1 | 6 | Chemie (SCN) | |||
| 7 | J (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | K, U (A, B) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 2 | Chemie (B3P) | |||
| 9 | S (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 10 | T (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 11 | V, W (A, B) | water | water | 18.0 | 1029 | Chemie (HOH) |
Sequence modifications
A, B: 7 - 531 (UniProt: P14618)
| PDB | External Database | Details |
|---|---|---|
| Tyr 437 | Ser 437 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114846.3 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1649.3 | |
| All* | Total formula weight | 116495.6 |
