6B31

Structure of RORgt in complex with a novel inverse agonist 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Nuclear receptor ROR-gamma	polymer	228	26615.8	2	UniProt (P51449) Pfam (PF00104) In PDB	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
2	A, B	(3S)-N~1~-(3-chloro-4-cyanophenyl)-N~5~-(1,3-diethyl-2,4-dioxo-1,2,3,4-tetrahydroquinazolin-6-yl)-3-methylpentanediamide	non-polymer		496.0	2	Chemie (CFJ)
3		water	water		18.0	15	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53231.7
Non-Polymers*	Number of molecules	2
	Total formula weight	991.9
All*	Total formula weight	54223.6

*Water molecules are not included.