6B1G

Solution structure of TDP-43 N-terminal domain dimer.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TAR DNA-binding protein 43, S48E Mutant	polymer	83	9244.3	1	UniProt (Q13148) Pfam (PF18694) In PDB	Homo sapiens (Human)	TDP-43
2	B	TAR DNA-binding protein 43, Y4R Mutant	polymer	83	9196.3	1	UniProt (Q13148) Pfam (PF18694) In PDB	Homo sapiens (Human)	TDP-43

Sequence modifications

A: 1 - 80 (UniProt: Q13148)

PDB	External Database	Details
Gly -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag
Glu 48	Ser 48	engineered mutation

B: 101 - 180 (UniProt: Q13148)

PDB	External Database	Details
Gly 98	-	expression tag
His 99	-	expression tag
Met 100	-	expression tag
Arg 104	Tyr 4	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	18440.7
All*	Total formula weight	18440.7

*Water molecules are not included.