6AWN
X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium-dependent serotonin transporter | polymer | 549 | 61703.8 | 1 | UniProt (P31645) Pfam (PF00209) | Homo sapiens (Human) | SERT,5HT transporter,5HTT,Solute carrier family 6 member 4 |
| 2 | B (B) | 8B6 antibody FAB heavy chain | polymer | 229 | 24853.6 | 1 | UniProt (A0A0F7R1P3) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) | |
| 3 | C (C) | 8B6 antibody FAB light chain | polymer | 214 | 23718.2 | 1 | UniProt (A0A0F7R5U8) Pfam (PF07686) Pfam (PF07654) | Mus musculus (Mouse) | |
| 4 | D, G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | E (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 6 | F (A) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) | |||
| 7 | H (A) | Paroxetine | non-polymer | 329.4 | 1 | Chemie (8PR) | |||
| 8 | I (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | J (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) |
Sequence modifications
A: 76 - 618 (UniProt: P31645)
B: 20 - 138 (PDB: 6AWN)
B: 139 - 237 (UniProt: A0A0F7R1P3)
C: 21 - 116 (PDB: 6AWN)
C: 117 - 234 (UniProt: A0A0F7R5U8)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
| Ser 75 | - | expression tag |
| Ala 110 | Tyr 110 | engineered mutation |
| Ala 291 | Ile 291 | engineered mutation |
| Ala 554 | Cys 554 | engineered mutation |
| Ala 580 | Cys 580 | engineered mutation |
| Leu 619 | - | expression tag |
| Val 620 | - | expression tag |
| Pro 621 | - | expression tag |
| Arg 622 | - | expression tag |
B: 139 - 237 (UniProt: A0A0F7R1P3)
| PDB | External Database | Details |
|---|---|---|
| Arg 238 | - | expression tag |
| Gly 239 | - | expression tag |
| Ser 240 | - | expression tag |
| His 241 | - | expression tag |
| His 242 | - | expression tag |
| His 243 | - | expression tag |
| His 244 | - | expression tag |
| His 245 | - | expression tag |
| His 246 | - | expression tag |
| His 247 | - | expression tag |
| His 248 | - | expression tag |
C: 117 - 234 (UniProt: A0A0F7R5U8)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 110275.6 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1727.5 | |
| All* | Total formula weight | 112003.1 |
