6AWN

X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central site

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sodium-dependent serotonin transporter	polymer	549	61703.8	1	UniProt (P31645) Pfam (PF00209) In PDB	Homo sapiens (Human)	SERT,5HT transporter,5HTT,Solute carrier family 6 member 4
2	B	8B6 antibody FAB heavy chain	polymer	229	24853.6	1	UniProt (A0A0F7R1P3) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (Mouse)
3	C	8B6 antibody FAB light chain	polymer	214	23718.2	1	UniProt (A0A0F7R5U8) Pfam (PF07686) Pfam (PF07654) In PDB	Mus musculus (Mouse)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	A	CHOLESTEROL	non-polymer		386.7	1	Chemie (CLR)
6	A	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	1	Chemie (LMT)
7	A	Paroxetine	non-polymer		329.4	1	Chemie (8PR)
8	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
9	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)

Sequence modifications

A: 76 - 618 (UniProt: P31645)

PDB	External Database	Details
Gly 74	-	expression tag
Ser 75	-	expression tag
Ala 110	Tyr 110	engineered mutation
Ala 291	Ile 291	engineered mutation
Ala 554	Cys 554	engineered mutation
Ala 580	Cys 580	engineered mutation
Leu 619	-	expression tag
Val 620	-	expression tag
Pro 621	-	expression tag
Arg 622	-	expression tag

B: 20 - 138 (PDB: 6AWN)
B: 139 - 237 (UniProt: A0A0F7R1P3)

PDB	External Database	Details
Arg 238	-	expression tag
Gly 239	-	expression tag
Ser 240	-	expression tag
His 241	-	expression tag
His 242	-	expression tag
His 243	-	expression tag
His 244	-	expression tag
His 245	-	expression tag
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag

C: 21 - 116 (PDB: 6AWN)
C: 117 - 234 (UniProt: A0A0F7R5U8)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	110275.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1727.5
All*	Total formula weight	112003.1

*Water molecules are not included.