6ATK
Crystal structure of the human coronavirus 229E spike protein receptor binding domain in complex with human aminopeptidase N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Aminopeptidase N | polymer | 905 | 103465.0 | 3 | UniProt (P15144) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | hAPN,Alanyl aminopeptidase,Aminopeptidase M,AP-M,Microsomal aminopeptidase,Myeloid plasma membrane glycoprotein CD13,gp150 |
| 2 | D, E, F (E, D, F) | Spike glycoprotein | polymer | 146 | 15868.1 | 3 | UniProt (P15423) Pfam (PF01600) | Human coronavirus 229E (HCoV-229E) | S glycoprotein,E2,Peplomer protein |
| 3 | G, H, I, J, K (G, H, I, J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 4 | AA, BA, CA, L, M... (E, D, A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 5 | P, U, Y (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
A, B, C: 66 - 967 (UniProt: P15144)
E, D, F: 293 - 435 (UniProt: P15423)
| PDB | External Database | Details |
|---|---|---|
| Gly 63 | - | expression tag |
| Arg 64 | - | expression tag |
| Pro 65 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 290 | - | expression tag |
| Arg 291 | - | expression tag |
| Pro 292 | - | expression tag |
| Met 300 | Thr 300 | conflict |
| Thr 414 | Ser 414 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 357999.3 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2122.0 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3514.3 | |
| All* | Total formula weight | 363635.6 |
