6ARU
Structure of Cetuximab Fab mutant in complex with EGFR extracellular domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 622 | 69015.6 | 1 | UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 |
2 | B | Cetuximab mutant light chain,Uncharacterized protein | polymer | 214 | 23504.9 | 1 | UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
3 | C | Cetuximab mutant heavy chain Fab fragment,Immunoglobulin gamma-1 heavy chain | polymer | 222 | 23829.6 | 1 | UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (Human) | |
4 | D | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G96786JM) | |||
5 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
6 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 1 - 616 (UniProt: P00533)
B: 1 - 106 (PDB: 6ARU)
B: 107 - 214 (UniProt: Q8TCD0)
C: 1 - 119 (PDB: 6ARU)
C: 120 - 222 (UniProt: P0DOX5)
PDB | External Database | Details |
---|---|---|
Lys 516 | Asn 540 | conflict |
Arg 610 | Glu 634 | conflict |
His 617 | - | expression tag |
His 618 | - | expression tag |
His 619 | - | expression tag |
His 620 | - | expression tag |
His 621 | - | expression tag |
His 622 | - | expression tag |
B: 107 - 214 (UniProt: Q8TCD0)
C: 1 - 119 (PDB: 6ARU)
C: 120 - 222 (UniProt: P0DOX5)
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 116350.1 | |
Branched | Number of molecules | 2 |
Total formula weight | 1821.6 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 663.6 | |
All* | Total formula weight | 118835.4 |