6ARQ

Crystal structure of CD96 (D1) bound to CD155/necl-5 (D1-3)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	T-cell surface protein tactile	polymer	128	14712.5	1	UniProt (P40200)	Homo sapiens (Human)	Cell surface antigen CD96,T cell-activated increased late expression protein
2	B (D)	Poliovirus receptor	polymer	317	34697.1	1	UniProt (P15151) Pfam (PF07686) Pfam (PF08205)	Homo sapiens (Human)	Nectin-like protein 5,NECL-5
3	C, D, E (B, C, E)	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	3	In PDB GlyTouCan (G86851RC)
4	F, G, H (A, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5	I, J (A, D)	water	water		18.0	8	Chemie (HOH)

Sequence modifications

A: 21 - 139 (UniProt: P40200)

PDB	External Database	Details
Thr 20	-	expression tag
Ser 110	Cys 110	engineered mutation
Gly 140	-	expression tag
Thr 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag
His 146	-	expression tag
His 147	-	expression tag

D: 28 - 334 (UniProt: P15151)

PDB	External Database	Details
Leu 26	-	expression tag
Glu 27	-	expression tag
Thr 335	-	expression tag
Ser 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	49409.6
Branched	Number of molecules	3
	Total formula weight	1102.0
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	51175.3

*Water molecules are not included.