6ARP

Structure of a mutant Cetuximab Fab fragment

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (C, A)	Cetuximab mutant light chain,Uncharacterized protein	polymer	214	23504.9	2	UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
2	B, D (D, B)	Cetuximab mutant Fab heavy chain,Immunoglobulin gamma-1 heavy chain	polymer	222	23829.6	2	UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654)	Homo sapiens (Human)
3	E, F, H, M (C, D, A)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	G, I, J, K, L... (C, D, B)	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
5	P, Q, R, S (C, D, A, B)	water	water		18.0	856	Chemie (HOH)

Sequence modifications

C, A: 1 - 106 (PDB: 6ARP)
C, A: 107 - 214 (UniProt: Q8TCD0)
D, B: 1 - 119 (PDB: 6ARP)
D, B: 120 - 222 (UniProt: P0DOX5)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	94669.1
Non-Polymers*	Number of molecules	11
	Total formula weight	1028.9
All*	Total formula weight	95698.0

*Water molecules are not included.