6ARH

Crystal structure of Human NAL at a resolution of 1.6 Angstrom

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	N-acetylneuraminate lyase	polymer	338	37266.6	4	UniProt (Q9BXD5) Pfam (PF00701) In PDB	Homo sapiens (Human)	NALase, N-acetylneuraminate pyruvate-lyase, N-acetylneuraminic acid aldolase, Sialate lyase,Sialate-pyruvate lyase, Sialic acid aldolase, Sialic acid lyase
2	A, B, C, D	ACETATE ION	non-polymer		59.0	8	Chemie (ACT)
3		water	water		18.0	1271	Chemie (HOH)

Sequence modifications

A, B, C, D: 3 - 322 (UniProt: Q9BXD5)

PDB	External Database	Details
Met -15	-	expression tag
Gly -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Gly -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Gly 1	-	expression tag
Ser 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	149066.3
Non-Polymers*	Number of molecules	8
	Total formula weight	472.4
All*	Total formula weight	149538.7

*Water molecules are not included.