6ARH
Crystal structure of Human NAL at a resolution of 1.6 Angstrom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| B | 0042802 | molecular_function | identical protein binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| C | 0042802 | molecular_function | identical protein binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008747 | molecular_function | N-acetylneuraminate lyase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019262 | biological_process | N-acetylneuraminate catabolic process |
| D | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 401 |
| Chain | Residue |
| A | ALA16 |
| A | GLY52 |
| A | THR53 |
| A | THR54 |
| A | TYR145 |
| A | LYS175 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 402 |
| Chain | Residue |
| A | HOH522 |
| A | HOH535 |
| D | TRP121 |
| A | GLY264 |
| A | VAL265 |
| A | LEU287 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 401 |
| Chain | Residue |
| B | ALA16 |
| B | PHE49 |
| B | GLY52 |
| B | THR53 |
| B | THR54 |
| B | TYR145 |
| B | LYS175 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 401 |
| Chain | Residue |
| C | ALA16 |
| C | GLY52 |
| C | THR53 |
| C | THR54 |
| C | TYR145 |
| C | LYS175 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 402 |
| Chain | Residue |
| B | TRP121 |
| C | GLY264 |
| C | VAL265 |
| C | LEU287 |
| C | HOH728 |
| C | HOH732 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue ACT C 403 |
| Chain | Residue |
| B | GLY264 |
| B | VAL265 |
| C | TRP121 |
| C | HOH727 |
| C | HOH755 |
| C | HOH914 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue ACT D 401 |
| Chain | Residue |
| D | ALA16 |
| D | PHE49 |
| D | GLY52 |
| D | THR53 |
| D | THR54 |
| D | TYR145 |
| D | LYS175 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue ACT D 402 |
| Chain | Residue |
| A | LEU118 |
| A | TRP121 |
| A | HOH659 |
| D | GLY264 |
| D | VAL265 |
| D | LEU287 |
| D | HOH550 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A6L4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"UniProtKB","id":"P0A6L4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0A6L4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
