6AOZ

Crystal structure of human FLASH N-terminal domain C54S/C83A (Crystal form 1)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (B, A, D, C)	CASP8-associated protein 2	polymer	96	11333.8	4	UniProt (Q9UKL3)	Homo sapiens (Human)	FLICE-associated huge protein
2	E, F, G, H (B, A, C)	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
3	I, J, K, L (B, A, D, C)	water	water		18.0	58	Chemie (HOH)

Sequence modifications

B, A, D, C: 51 - 137 (UniProt: Q9UKL3)

PDB	External Database	Details
Met 50	-	initiating methionine
Ser 54	Cys 54	engineered mutation
Ala 83	Cys 83	engineered mutation
Ala 99	Thr 99	variant
Leu 138	-	expression tag
Glu 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	45335.1
Non-Polymers*	Number of molecules	4
	Total formula weight	248.3
All*	Total formula weight	45583.3

*Water molecules are not included.