6AN6

Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	polymer	158	17966.5	2	UniProt (P26281) Pfam (PF01288) In PDB	Escherichia coli (strain K12)	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase,PPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase,HPPK
2	A, B	5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine	non-polymer		682.6	2	Chemie (J1I)
3		water	water		18.0	142	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35933.1
Non-Polymers*	Number of molecules	2
	Total formula weight	1365.3
All*	Total formula weight	37298.4

*Water molecules are not included.