Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046656 | biological_process | folic acid biosynthetic process |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue J1I A 201 |
Chain | Residue |
A | THR42 |
A | ILE98 |
A | ARG110 |
A | LEU111 |
A | THR112 |
A | HIS115 |
A | TYR116 |
A | ARG121 |
A | PHE123 |
A | HOH311 |
A | HOH320 |
A | PRO43 |
A | HOH328 |
A | PRO44 |
A | LEU45 |
A | TYR53 |
A | ASN55 |
A | GLN74 |
A | ASP95 |
A | ASP97 |
site_id | AC2 |
Number of Residues | 20 |
Details | binding site for residue J1I B 201 |
Chain | Residue |
B | THR42 |
B | PRO43 |
B | PRO44 |
B | LEU45 |
B | TYR53 |
B | ASN55 |
B | ASP95 |
B | ASP97 |
B | ILE98 |
B | ARG110 |
B | LEU111 |
B | THR112 |
B | VAL113 |
B | HIS115 |
B | TYR116 |
B | ARG121 |
B | PHE123 |
B | HIS148 |
B | HOH324 |
B | HOH326 |
Functional Information from PROSITE/UniProt
site_id | PS00794 |
Number of Residues | 12 |
Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDLDIM |
Chain | Residue | Details |
A | ARG88-MET99 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 151 |
Chain | Residue | Details |
A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
A | ASP95 | metal ligand |
A | ASP97 | metal ligand |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 151 |
Chain | Residue | Details |
B | ARG82 | electrostatic stabiliser, hydrogen bond donor |
B | ARG92 | electrostatic stabiliser, hydrogen bond donor |
B | ASP95 | metal ligand |
B | ASP97 | metal ligand |