6AK3
Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Prostaglandin E2 receptor EP3 subtype,Soluble cytochrome b562 | polymer | 418 | 46044.7 | 2 | UniProt (P43115) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | PGE2 receptor EP3 subtype,PGE2-R,Prostanoid EP3 receptor,Cytochrome b-562 |
2 | B, A | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid | non-polymer | 352.5 | 2 | Chemie (P2E) | |||
3 | B, A | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 2 | Chemie (POV) |
Sequence modifications
B, A: 43 - 359 (UniProt: P43115)
B, A: 1001 - 1040 (UniProt: P0ABE7)
B, A: 1063 - 1105 (UniProt: P0ABE7)
PDB | External Database | Details |
---|---|---|
Gly 39 | - | expression tag |
Pro 40 | - | expression tag |
Thr 41 | - | expression tag |
Ser 42 | - | expression tag |
Ile 173 | Ala 173 | engineered mutation |
Ser 185 | Val 185 | engineered mutation |
Gln 217 | Asn 217 | engineered mutation |
Asp 258 | Ser 258 | engineered mutation |
Leu 289 | Cys 289 | engineered mutation |
Gln 308 | Asn 308 | engineered mutation |
Leu 360 | - | linker |
Glu 361 | - | linker |
Leu 362 | - | linker |
Glu 363 | - | linker |
Val 364 | - | linker |
Leu 365 | - | linker |
Phe 366 | - | linker |
Gln 367 | - | linker |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1041 | - | linker |
Ser 1042 | - | linker |
Gly 1043 | - | linker |
Ser 1044 | - | linker |
Gly 1045 | - | linker |
Ile 1098 | Arg 120 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Gly 1106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 92089.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2225.1 | |
All* | Total formula weight | 94314.5 |