6AK3
Crystal structure of the human prostaglandin E receptor EP3 bound to prostaglandin E2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004955 | molecular_function | prostaglandin receptor activity |
| A | 0004957 | molecular_function | prostaglandin E receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004955 | molecular_function | prostaglandin receptor activity |
| B | 0004957 | molecular_function | prostaglandin E receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue P2E B 1201 |
| Chain | Residue |
| B | MET58 |
| B | ARG333 |
| B | SER336 |
| B | GLN339 |
| B | GLN103 |
| B | THR106 |
| B | THR107 |
| B | VAL110 |
| B | TYR114 |
| B | MET137 |
| B | THR206 |
| B | TRP207 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue POV B 1202 |
| Chain | Residue |
| A | SER49 |
| A | ILE330 |
| A | ARG333 |
| A | LEU341 |
| B | VAL50 |
| B | SER51 |
| B | VAL52 |
| B | ALA53 |
| B | THR57 |
| B | TYR114 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue P2E A 1201 |
| Chain | Residue |
| A | MET58 |
| A | GLN103 |
| A | THR106 |
| A | THR107 |
| A | VAL110 |
| A | TYR114 |
| A | MET137 |
| A | THR206 |
| A | TRP207 |
| A | LEU329 |
| A | ARG333 |
| A | SER336 |
| A | GLN339 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue POV A 1202 |
| Chain | Residue |
| A | VAL50 |
| A | SER51 |
| A | VAL52 |
| A | ALA53 |
| A | THR57 |
| A | LEU60 |
| B | GLY48 |
| B | SER49 |
| B | ILE330 |
| B | ARG333 |
Functional Information from PROSITE/UniProt
| site_id | PS00626 |
| Number of Residues | 11 |
| Details | RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. AGSGsGHGFDI |
| Chain | Residue | Details |
| B | ALA1040-ILE1067 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE54-ARG78 | |
| A | PHE54-ARG78 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 124 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| B | ARG79-CYS91 | |
| B | GLU154-ARG175 | |
| B | LYS254-GLN283 | |
| A | ARG79-CYS91 | |
| A | GLU154-ARG175 | |
| A | LYS254-GLN283 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE92-VAL112 | |
| A | ILE92-VAL112 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 132 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| B | VAL113-THR131 | |
| B | GLN198-ASN227 | |
| B | GLN308-PHE327 | |
| A | VAL113-THR131 | |
| A | GLN198-ASN227 | |
| A | GLN308-PHE327 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE132-VAL153 | |
| A | PHE132-VAL153 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| B | ALA176-GLY197 | |
| A | ALA176-GLY197 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU228-ILE253 | |
| A | LEU228-ILE253 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU284-PHE307 | |
| A | LEU284-PHE307 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| B | PHE328-LEU349 | |
| A | PHE328-LEU349 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| B | TRP1007 | |
| B | ILE1102 | |
| A | TRP1007 | |
| A | ILE1102 |
