6AJY

Crystal structure of BRD4 in complex with 2',4'-dihydroxy-2-methoxychalcone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Bromodomain-containing protein 4	polymer	135	16160.6	1	UniProt (O60885) Pfam (PF00439) In PDB	Homo sapiens (Human)	Protein HUNK1
2	A	2',4'-dihydroxy-2-methoxychalcone	non-polymer		270.3	1	Chemie (A0R)
3	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4		water	water		18.0	91	Chemie (HOH)

Sequence modifications

A: 42 - 168 (UniProt: O60885)

PDB	External Database	Details
Met 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
Met 41	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16160.6
Non-Polymers*	Number of molecules	3
	Total formula weight	316.3
All*	Total formula weight	16476.8

*Water molecules are not included.