6AJX

Crystal structure of BRD4 in complex with isoliquiritigenin in the absence of DMSO

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Bromodomain-containing protein 4	polymer	135	16160.6	1	UniProt (O60885) Pfam (PF00439) In PDB	Homo sapiens (Human)	Protein HUNK1
2	A	2',4,4'-TRIHYDROXYCHALCONE	non-polymer		256.3	1	Chemie (HCC)
3	A	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
4		water	water		18.0	43	Chemie (HOH)

Sequence modifications

A: 42 - 168 (UniProt: O60885)

PDB	External Database	Details
Met 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
Met 41	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	16160.6
Non-Polymers*	Number of molecules	3
	Total formula weight	302.2
All*	Total formula weight	16462.8

*Water molecules are not included.