6AJX
Crystal structure of BRD4 in complex with isoliquiritigenin in the absence of DMSO
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 135 | 16160.6 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B (A) | 2',4,4'-TRIHYDROXYCHALCONE | non-polymer | 256.3 | 1 | Chemie (HCC) | |||
| 3 | C, D (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | E (A) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 42 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Met 34 | - | expression tag |
| His 35 | - | expression tag |
| His 36 | - | expression tag |
| His 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| Met 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16160.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 302.2 | |
| All* | Total formula weight | 16462.8 |
