6AJC
Crystal structure of Trypanosoma cruzi cytosolic isocitrate dehydrogenase in complex with NADP+, isocitrate and ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Isocitrate dehydrogenase [NADP] | polymer | 413 | 46881.6 | 8 | UniProt (Q4E4L7) Pfam (PF00180) In PDB | Trypanosoma cruzi (strain CL Brener) | |
| 2 | G, H, A, B, C... | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 8 | Chemie (NAP) | |||
| 3 | G, H, A, B, C... | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) | |||
| 4 | G, H, A, B, C... | ISOCITRIC ACID | non-polymer | 192.1 | 8 | Chemie (ICT) | |||
| 5 | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 413 (UniProt: Q4E4L7)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | Met 1 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 375053.1 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 7804.9 | |
| All* | Total formula weight | 382857.9 |
