6AJA
Crystal structure of Trypanosoma brucei glycosomal isocitrate dehydrogenase in complex with NADPH, alpha-ketoglutarate and ca2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isocitrate dehydrogenase [NADP] | polymer | 413 | 46791.6 | 4 | UniProt (Q387G0) Pfam (PF00180) | Trypanosoma brucei brucei | |
| 2 | E, J, K, O (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 3 | F, I, L, P (A, C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 4 | G, H, M, N (A, C) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) PubChem (753) | |||
| 5 | Q (D) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) PubChem (51) | |||
| 6 | R, S, T, U (A, B, C, D) | water | water | 18.0 | 64 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 413 (UniProt: Q387G0)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | Met 1 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 187166.4 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3648.4 | |
| All* | Total formula weight | 190814.8 |
